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Mitochondria-derived peptides in aging and healthspan

Brendan Miller, Su-Jeong Kim, Hiroshi Kumagai, Kelvin Yen, Pinchas Cohen

Journal of Clinical Investigation · 2022 · ▲ 104 citations

Mitochondrial dysfunction Human Review

Abstract

The mechanisms that explain mitochondrial dysfunction in aging and healthspan continue to be studied, but one element has been unexplored: microproteins. Small open reading frames in circular mitochondria DNA can encode multiple microproteins, called mitochondria-derived peptides (MDPs). Currently, eight MDPs have been published: humanin, MOTS-c, and SHLPs 1-6. This Review describes recent advances in microprotein discovery with a focus on MDPs. It discusses what is currently known about MDPs in aging and how this new understanding could add to the way we understand age-related diseases including type 2 diabetes, cancer, and neurodegenerative diseases at the genomic, proteomic, and drug-development levels.

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Provenance

Source: OpenAlex
DOI: 10.1172/jci158449
Canonical: link ↗
Fetched: 2026-06-22 MST

Cite this

APA

Miller, B., Kim, S., Kumagai, H., Yen, K., & Cohen, P. (2022). Mitochondria-derived peptides in aging and healthspan. <em>Journal of Clinical Investigation</em>. https://doi.org/10.1172/jci158449

Vancouver

Miller B, Kim S, Kumagai H, Yen K, Cohen P. Mitochondria-derived peptides in aging and healthspan. Journal of Clinical Investigation. 2022. doi:10.1172/jci158449.

BibTeX

@article{brendan2022Mitoch, title = {Mitochondria-derived peptides in aging and healthspan}, author = {Brendan Miller and Su-Jeong Kim and Hiroshi Kumagai and Kelvin Yen and Pinchas Cohen}, journal = {Journal of Clinical Investigation}, year = {2022}, doi = {10.1172/jci158449}, }