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Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains

Ahmad Jowaed, Ina Schmitt, Oliver Kaut, Ullrich Wüllner

Journal of Neuroscience · 2010 · ▲ 436 citations

Epigenetic alterations Human

Abstract

Alpha-synuclein (SNCA) is a major risk gene for Parkinson's disease (PD), and increased SNCA gene dosage results in a parkinsonian syndrome in affected families. We found that methylation of human SNCA intron 1 decreased gene expression, while inhibition of DNA methylation activated SNCA expression. Methylation of SNCA intron 1 was reduced in DNA from sporadic PD patients' substantia nigra, putamen, and cortex, pointing toward a yet unappreciated epigenetic regulation of SNCA expression in PD.

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Provenance

Source: OpenAlex
DOI: 10.1523/jneurosci.6119-09.2010
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Fetched: 2026-10-20 MST

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APA

Jowaed, A., Schmitt, I., Kaut, O., & Wüllner, U. (2010). Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains. <em>Journal of Neuroscience</em>. https://doi.org/10.1523/jneurosci.6119-09.2010

Vancouver

Jowaed A, Schmitt I, Kaut O, Wüllner U. Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains. Journal of Neuroscience. 2010. doi:10.1523/jneurosci.6119-09.2010.

BibTeX

@article{ahmad2010Methyl, title = {Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains}, author = {Ahmad Jowaed and Ina Schmitt and Oliver Kaut and Ullrich Wüllner}, journal = {Journal of Neuroscience}, year = {2010}, doi = {10.1523/jneurosci.6119-09.2010}, }