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Methylation of ELOVL 2 gene as a new epigenetic marker of age

Paolo Garagnani, Maria Giulia Bacalini, Chiara Pirazzini, Davide Gori, Cristina Giuliani, Daniela Mari, Anna Maria Di Blasio, Davide Gentilini, Giovanni Vitale, Sebastiano Collino, Serge Rezzi, Gastone Castellani, Miriam Capri, Stefano Salvioli, Claudio Franceschi

Aging Cell · 2012 · ▲ 510 citations

Epigenetic alterations Human

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Abstract

The discovery of biomarkers able to predict biological age of individuals is a crucial goal in aging research. Recently, researchers' attention has turn toward epigenetic markers of aging. Using the Illumina Infinium HumanMethylation450 BeadChip on whole blood DNA from a small cohort of 64 subjects of different ages, we identified 3 regions, the CpG islands of ELOVL2, FHL2, and PENK genes, whose methylation level strongly correlates with age. These results were confirmed by the Sequenom's EpiTYPER assay on a larger cohort of 501 subjects from 9 to 99 years, including 7 cord blood samples. Among the 3 genes, ELOVL2 shows a progressive increase in methylation that begins since the very first stage of life (Spearman's correlation coefficient = 0.92) and appears to be a very promising biomarker of aging.

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Provenance

Source: OpenAlex
DOI: 10.1111/acel.12005
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Fetched: 2026-09-22 MST

Cite this

APA

Garagnani, P., Bacalini, M.G., Pirazzini, C., Gori, D., Giuliani, C., Mari, D., Blasio, A.M.D., Gentilini, D., Vitale, G., Collino, S., Rezzi, S., Castellani, G., Capri, M., Salvioli, S., & Franceschi, C. (2012). Methylation of ELOVL 2 gene as a new epigenetic marker of age. <em>Aging Cell</em>. https://doi.org/10.1111/acel.12005

Vancouver

Garagnani P, Bacalini MG, Pirazzini C, Gori D, Giuliani C, Mari D, et al. Methylation of ELOVL 2 gene as a new epigenetic marker of age. Aging Cell. 2012. doi:10.1111/acel.12005.

BibTeX

@unpublished{paolo2012Methyl, title = {Methylation of ELOVL 2 gene as a new epigenetic marker of age}, author = {Paolo Garagnani and Maria Giulia Bacalini and Chiara Pirazzini and Davide Gori and Cristina Giuliani and Daniela Mari and Anna Maria Di Blasio and Davide Gentilini and Giovanni Vitale and Sebastiano Collino and Serge Rezzi and Gastone Castellani and Miriam Capri and Stefano Salvioli and Claudio Franceschi}, journal = {Aging Cell}, year = {2012}, doi = {10.1111/acel.12005}, }