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Identification of Tropical Plant Extracts That Extend Yeast Chronological Life Span

Mandy Kwong, Jee Whu Lee, Mohammed Razip Samian, Habibah A. Wahab, Nobumoto Watanabe, Eugene Boon Beng Ong

Cells · 2021 · ▲ 10 citations

Altered intercellular communication Yeast

Abstract

Certain plant extracts (PEs) contain bioactive compounds that have antioxidant and lifespan-extending activities on organisms. These PEs play different roles in cellular processes, such as enhancing stress resistance and modulating longevity-defined signaling pathways that contribute to longevity. Here, we report the discovery of PEs that extended chronological life span (CLS) in budding yeast from a screen of 222 PEs. We identified two PEs, the leaf extracts of Manihot esculenta and Wodyetia bifurcata that extended CLS in a dose-dependent manner. The CLS-extending PEs also conferred oxidative stress tolerance, suggesting that these PEs might extend yeast CLS through the upregulation of stress response pathways.

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Provenance

Source: OpenAlex
DOI: 10.3390/cells10102718
Canonical: link ↗
Fetched: 2026-08-04 MST

Cite this

APA

Kwong, M., Lee, J.W., Samian, M.R., Wahab, H.A., Watanabe, N., & Ong, E.B.B. (2021). Identification of Tropical Plant Extracts That Extend Yeast Chronological Life Span. <em>Cells</em>. https://doi.org/10.3390/cells10102718

Vancouver

Kwong M, Lee JW, Samian MR, Wahab HA, Watanabe N, Ong EBB. Identification of Tropical Plant Extracts That Extend Yeast Chronological Life Span. Cells. 2021. doi:10.3390/cells10102718.

BibTeX

@article{mandy2021Identi, title = {Identification of Tropical Plant Extracts That Extend Yeast Chronological Life Span}, author = {Mandy Kwong and Jee Whu Lee and Mohammed Razip Samian and Habibah A. Wahab and Nobumoto Watanabe and Eugene Boon Beng Ong}, journal = {Cells}, year = {2021}, doi = {10.3390/cells10102718}, }