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Growth and aging: a common molecular mechanism

Mikhail V. Blagosklonny, Michael N. Hall

Aging · 2009 · ▲ 215 citations

Altered intercellular communication Yeast Human Review

Abstract

It is commonly assumed that growth and aging are somehow linked, but the nature of this link has been elusive. Here we review the aging process as a continuation of TOR-driven growth. TOR is absolutely essential for developmental growth, but upon completion of development it causes aging and age-related diseases. Thus, the nutrient-sensing and growth-promoting TOR signaling pathway may provide a molecular link between growth and aging that is universal from yeast to human.

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Provenance

Source: OpenAlex
DOI: 10.18632/aging.100040
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Fetched: 2026-07-22 MST

Cite this

APA

Blagosklonny, M.V., & Hall, M.N. (2009). Growth and aging: a common molecular mechanism. <em>Aging</em>. https://doi.org/10.18632/aging.100040

Vancouver

Blagosklonny MV, Hall MN. Growth and aging: a common molecular mechanism. Aging. 2009. doi:10.18632/aging.100040.

BibTeX

@article{mikhail2009Growth, title = {Growth and aging: a common molecular mechanism}, author = {Mikhail V. Blagosklonny and Michael N. Hall}, journal = {Aging}, year = {2009}, doi = {10.18632/aging.100040}, }