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Glutamate uptake is decreased in platelets from Alzheimer's disease patients

Carlo Ferrarese, Barbara Begni, Carla Canevari, C Zoia, Roberto Piolti, Maura Frigo, Ildebrando Marco Appollonio, Lodovico Frattola

Annals of Neurology · 2000 · ▲ 77 citations

Mitochondrial dysfunction Human

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Abstract

Because excitotoxicity may be involved in neurodegeneration in Alzheimer's disease, we investigated possible modifications of platelet glutamate uptake in AD patients. High-affinity glutamate uptake was studied in platelets from 35 Alzheimer's disease patients, 10 multi-infarct dementia patients, and 35 age-matched normal controls; it was decreased by 40% in platelets from Alzheimer's disease patients compared with controls and with multi-infarct dementia patients. Platelet glutamate uptake could be used as peripheral marker of glutamatergic involvement and as adjunctive diagnostic tool in Alzheimer's disease patients.

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Provenance

Source: OpenAlex
DOI: 10.1002/1531-8249(200005)47:5<641::aid-ana12>3.0.co;2-i
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Fetched: 2026-10-17 MST

Cite this

APA

Ferrarese, C., Begni, B., Canevari, C., Zoia, C., Piolti, R., Frigo, M., Appollonio, I.M., & Frattola, L. (2000). Glutamate uptake is decreased in platelets from Alzheimer's disease patients. <em>Annals of Neurology</em>. https://doi.org/10.1002/1531-8249(200005)47:5<641::aid-ana12>3.0.co;2-i

Vancouver

Ferrarese C, Begni B, Canevari C, Zoia C, Piolti R, Frigo M, et al. Glutamate uptake is decreased in platelets from Alzheimer's disease patients. Annals of Neurology. 2000. doi:10.1002/1531-8249(200005)47:5<641::aid-ana12>3.0.co;2-i.

BibTeX

@article{carlo2000Glutam, title = {Glutamate uptake is decreased in platelets from Alzheimer's disease patients}, author = {Carlo Ferrarese and Barbara Begni and Carla Canevari and C Zoia and Roberto Piolti and Maura Frigo and Ildebrando Marco Appollonio and Lodovico Frattola}, journal = {Annals of Neurology}, year = {2000}, doi = {10.1002/1531-8249(200005)47:5<641::aid-ana12>3.0.co;2-i}, }