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From Powerhouse to Perpetrator—Mitochondria in Health and Disease

Nima Borhan Fakouri, Thomas Lau Hansen, Claus Desler, Sharath Anugula, Lene Juel Rasmussen

Biology · 2019 · ▲ 16 citations

Genomic instability Mitochondrial dysfunction Altered intercellular communication Human Review

Abstract

In this review we discuss the interaction between metabolic stress, mitochondrial dysfunction, and genomic instability. Unrepaired DNA damage in the nucleus resulting from excess accumulation of DNA damages and stalled replication can initiate cellular signaling responses that negatively affect metabolism and mitochondrial function. On the other hand, mitochondrial pathologies can also lead to stress in the nucleus, and cause sensitivity to DNA-damaging agents. These are examples of how hallmarks of cancer and aging are connected and influenced by each other to protect humans from disease.

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Provenance

Source: OpenAlex
DOI: 10.3390/biology8020035
Canonical: link ↗
Fetched: 2026-06-02 MST

Cite this

APA

Fakouri, N.B., Hansen, T.L., Desler, C., Anugula, S., & Rasmussen, L.J. (2019). From Powerhouse to Perpetrator—Mitochondria in Health and Disease. <em>Biology</em>. https://doi.org/10.3390/biology8020035

Vancouver

Fakouri NB, Hansen TL, Desler C, Anugula S, Rasmussen LJ. From Powerhouse to Perpetrator—Mitochondria in Health and Disease. Biology. 2019. doi:10.3390/biology8020035.

BibTeX

@article{nima2019FromPo, title = {From Powerhouse to Perpetrator—Mitochondria in Health and Disease}, author = {Nima Borhan Fakouri and Thomas Lau Hansen and Claus Desler and Sharath Anugula and Lene Juel Rasmussen}, journal = {Biology}, year = {2019}, doi = {10.3390/biology8020035}, }