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Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis

Bruce Richardson, Lee Scheinbart, John R. Strahler, Laura A. Gross, Samir Hanash, Marcia A Johnson

Arthritis & Rheumatism · 1990 · ▲ 563 citations

Epigenetic alterations Human

Abstract

Procainamide and hydralazine inhibit T cell DNA methylation and induce autoreactivity in cloned CD4+ T cells. These drugs also induce an autoimmune syndrome, suggesting a possible relationship between DNA hypomethylation, T cell autoreactivity, and certain autoimmune diseases. To test this relationship, DNA methylation was studied in T cells from patients with rheumatoid arthritis and patients with systemic lupus erythematosus, and was found to be impaired. These results support a relationship between DNA hypomethylation and some forms of autoimmune disease.

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Provenance

Source: OpenAlex
DOI: 10.1002/art.1780331109
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Fetched: 2026-08-30 MST

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APA

Richardson, B., Scheinbart, L., Strahler, J.R., Gross, L.A., Hanash, S., & Johnson, M.A. (1990). Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis. <em>Arthritis & Rheumatism</em>. https://doi.org/10.1002/art.1780331109

Vancouver

Richardson B, Scheinbart L, Strahler JR, Gross LA, Hanash S, Johnson MA. Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis & Rheumatism. 1990. doi:10.1002/art.1780331109.

BibTeX

@unpublished{bruce1990Eviden, title = {Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis}, author = {Bruce Richardson and Lee Scheinbart and John R. Strahler and Laura A. Gross and Samir Hanash and Marcia A Johnson}, journal = {Arthritis & Rheumatism}, year = {1990}, doi = {10.1002/art.1780331109}, }