Open access · OA via OpenAlex

Epigenetics and cancer

Genes & Development · 2004 · ▲ 482 citations

Genomic instability Epigenetic alterations

Abstract

Epigenetic mechanisms act to change the accessibility of chromatin to transcriptional regulation locally and globally via modifications of the DNA and by modification or rearrangement of nucleosomes. Epigenetic gene regulation collaborates with genetic alterations in cancer development. This is evident from every aspect of tumor biology including cell growth and differentiation, cell cycle control, DNA repair, angiogenesis, migration, and evasion of host immunosurveillance. In contrast to genetic cancer causes, the possibility of reversing epigenetic codes may provide new targets for therapeutic intervention.

◌ CITATION ONLY
Full text is not openly licensed for redistribution here. Read it at the source:

Read at source →

Provenance

Source: OpenAlex
DOI: 10.1101/gad.1232504
Canonical: link ↗
Fetched: 2026-06-09 MST

Cite this

APA

Lund, A.H., & Lohuizen, M.V. (2004). Epigenetics and cancer. <em>Genes & Development</em>. https://doi.org/10.1101/gad.1232504

Vancouver

Lund AH, Lohuizen MV. Epigenetics and cancer. Genes & Development. 2004. doi:10.1101/gad.1232504.

BibTeX

@article{anders2004Epigen, title = {Epigenetics and cancer}, author = {Anders H. Lund and Maarten van Lohuizen}, journal = {Genes & Development}, year = {2004}, doi = {10.1101/gad.1232504}, }