Open access · OA via OpenAlex

Epigenetic Modifications in Cardiovascular Aging and Diseases

Weiqi Zhang, Moshi Song, Jing Qu, Guang‐Hui Liu

Circulation Research · 2018 · ▲ 283 citations

Epigenetic alterations Review

Abstract

Aging is associated with a progressive decline in cardiovascular structure and function. Accumulating evidence links cardiovascular aging to epigenetic alterations encompassing a complex interplay of DNA methylation, histone posttranslational modifications, and dynamic nucleosome occupancy governed by numerous epigenetic factors. Advances in genomics technology have led to a profound understanding of chromatin reorganization in both cardiovascular aging and diseases. This review summarizes recent discoveries in epigenetic mechanisms involved in cardiovascular aging and diseases and discusses potential therapeutic strategies to retard cardiovascular aging and conquer related diseases through the rejuvenation of epigenetic signatures to a young state.

◌ CITATION ONLY
Full text is not openly licensed for redistribution here. Read it at the source:

Read at source →

Provenance

Source: OpenAlex
DOI: 10.1161/circresaha.118.312497
Canonical: link ↗
Fetched: 2026-06-02 MST

Cite this

APA

Zhang, W., Song, M., Qu, J., & Liu, G. (2018). Epigenetic Modifications in Cardiovascular Aging and Diseases. <em>Circulation Research</em>. https://doi.org/10.1161/circresaha.118.312497

Vancouver

Zhang W, Song M, Qu J, Liu G. Epigenetic Modifications in Cardiovascular Aging and Diseases. Circulation Research. 2018. doi:10.1161/circresaha.118.312497.

BibTeX

@article{weiqi2018Epigen, title = {Epigenetic Modifications in Cardiovascular Aging and Diseases}, author = {Weiqi Zhang and Moshi Song and Jing Qu and Guang‐Hui Liu}, journal = {Circulation Research}, year = {2018}, doi = {10.1161/circresaha.118.312497}, }