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Epigenetic changes associated with oocyte aging

Xingwei Liang, Junyu Ma, Heide Schatten, Qing‐Yuan Sun

Science China Life Sciences · 2012 · ▲ 37 citations

Epigenetic alterations Review

Abstract

It is well established that the decline in female reproductive outcomes is related to postovulatory aging of oocytes and advanced maternal age. Poor oocyte quality is correlated with compromised genetic integrity and epigenetic changes during the oocyte aging process. Here, we review the epigenetic alterations, mainly focused on DNA methylation, histone acetylation and methylation associated with postovulatory oocyte aging as well as advanced maternal age. Furthermore, we address the underlying epigenetic mechanisms that contribute to the decline in oocyte quality during oocyte aging.

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Provenance

Source: OpenAlex
DOI: 10.1007/s11427-012-4354-3
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Fetched: 2026-06-03 MST

Cite this

APA

Liang, X., Ma, J., Schatten, H., & Sun, Q. (2012). Epigenetic changes associated with oocyte aging. <em>Science China Life Sciences</em>. https://doi.org/10.1007/s11427-012-4354-3

Vancouver

Liang X, Ma J, Schatten H, Sun Q. Epigenetic changes associated with oocyte aging. Science China Life Sciences. 2012. doi:10.1007/s11427-012-4354-3.

BibTeX

@article{xingwei2012Epigen, title = {Epigenetic changes associated with oocyte aging}, author = {Xingwei Liang and Junyu Ma and Heide Schatten and Qing‐Yuan Sun}, journal = {Science China Life Sciences}, year = {2012}, doi = {10.1007/s11427-012-4354-3}, }