Preprint · CC-BY via OpenAlex

DNA methylation GrimAge strongly predicts lifespan and healthspan

Ake T. Lu, Austin Quach, James G. Wilson, Alex P. Reiner, Abraham Aviv, Kenneth Raj, Lifang Hou, Andrea Baccarelli, Yun Li, James D. Stewart, Eric A. Whitsel, Themistocles L. Assimes, Luigi Ferrucci, Steve Horvath

Aging · 2019 · ▲ 2,547 citations

Epigenetic alterations Human

＋ Sign in to save

Abstract

.Using large scale validation data from thousands of individuals, we demonstrate that DNAm GrimAge stands out among existing epigenetic clocks in terms of its predictive ability for time-to-death (Cox regression P=2.0E-75), time-to-coronary heart disease (Cox P=6.2E-24), time-to-cancer (P= 1.3E-12), its strong relationship with computed tomography data for fatty liver/excess visceral fat, and age-at-menopause (P=1.6E-12). AgeAccelGrim is strongly associated with a host of age-related conditions including comorbidity count (P=3.45E-17). Similarly, age-adjusted DNAm PAI-1 levels are associated with lifespan (P=5.4E-28), comorbidity count (P= 7.3E-56) and type 2 diabetes (P=2.0E-26). These DNAm-based biomarkers show the expected relationship with lifestyle factors including healthy diet and educational attainment.Overall, these epigenetic biomarkers are expected to find many applications including human anti-aging studies.

◌ CITATION ONLY
Full text is not openly licensed for redistribution here. Read it at the source:

Read at source →

Provenance

Source: OpenAlex
DOI: 10.18632/aging.101684
Canonical: link ↗
Fetched: 2026-05-31 MST

Cite this

APA

Lu, A.T., Quach, A., Wilson, J.G., Reiner, A.P., Aviv, A., Raj, K., Hou, L., Baccarelli, A., Li, Y., Stewart, J.D., Whitsel, E.A., Assimes, T.L., Ferrucci, L., & Horvath, S. (2019). DNA methylation GrimAge strongly predicts lifespan and healthspan. <em>Aging</em>. https://doi.org/10.18632/aging.101684

Vancouver

Lu AT, Quach A, Wilson JG, Reiner AP, Aviv A, Raj K, et al. DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging. 2019. doi:10.18632/aging.101684.

BibTeX

@unpublished{ake2019DNAmet, title = {DNA methylation GrimAge strongly predicts lifespan and healthspan}, author = {Ake T. Lu and Austin Quach and James G. Wilson and Alex P. Reiner and Abraham Aviv and Kenneth Raj and Lifang Hou and Andrea Baccarelli and Yun Li and James D. Stewart and Eric A. Whitsel and Themistocles L. Assimes and Luigi Ferrucci and Steve Horvath}, journal = {Aging}, year = {2019}, doi = {10.18632/aging.101684}, }