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DNA methylation alterations in Alzheimer’s disease

Amy S. Yokoyama, John C. Rutledge, Valentina Medici

Current Zoology · 2017 · ▲ 80 citations

Epigenetic alterations Human Review

Abstract

The observation that Alzheimer's disease (AD) patients with similar and even identical genetic backgrounds often present with heterogeneous pathologies has prompted the hypothesis that epigenetics may contribute to AD. While the study of epigenetics encompasses a variety of modifications including histone modifications and non-coding RNAs, much of the research on how epigenetics might impact AD pathology has been focused on DNA methylation. To this end, several studies have characterized DNA methylation alterations in various brain regions of individuals with AD, with conflicting results. This review examines the results of studies analyzing both global and gene-specific DNA methylation changes in AD and also assesses the results of studies analyzing DNA hydroxymethylation in patients with AD.

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Provenance

Source: OpenAlex
DOI: 10.1093/eep/dvx008
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Fetched: 2026-06-09 MST

Cite this

APA

Yokoyama, A.S., Rutledge, J.C., & Medici, V. (2017). DNA methylation alterations in Alzheimer’s disease. <em>Current Zoology</em>. https://doi.org/10.1093/eep/dvx008

Vancouver

Yokoyama AS, Rutledge JC, Medici V. DNA methylation alterations in Alzheimer’s disease. Current Zoology. 2017. doi:10.1093/eep/dvx008.

BibTeX

@article{amy2017DNAmet, title = {DNA methylation alterations in Alzheimer’s disease}, author = {Amy S. Yokoyama and John C. Rutledge and Valentina Medici}, journal = {Current Zoology}, year = {2017}, doi = {10.1093/eep/dvx008}, }