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DNA methylation age acceleration is associated with ALS age of onset and survival

Ming Zhang, Paul M. McKeever, Zhengrui Xi, Danielle Moreno, Christine Sato, Tessa Bergsma, Philip McGoldrick, Julia Keith, Janice Robertson, Lorne Zinman, Ekaterina Rogaeva

Acta Neuropathologica · 2020 · ▲ 55 citations

Epigenetic alterations Human

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Abstract

C9orf72-carriers and identical twins DNA methylation (DNAm) is a key epigenetic modification and linked to the risk of several neurodegenerative diseases (Supplementary introduction). The cumulative assessment of DNAm levels at age-related CpGs allows the estimation of multi-tissue DNAm age (epigenetic clock), which could be more accurate for assessing biological age than chronological age. Hypermethylation of the CpG-island 5 of the C9orf72-repeat and DNAm-age acceleration have been reported to be associated with C9orf72-disease duration and age of onset However, epigenetic modifiers in genetically unexplained ALS patients are largely unknown.

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Provenance

Source: OpenAlex
DOI: 10.1007/s00401-020-02131-z
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Fetched: 2026-07-15 MST

Cite this

APA

Zhang, M., McKeever, P.M., Xi, Z., Moreno, D., Sato, C., Bergsma, T., McGoldrick, P., Keith, J., Robertson, J., Zinman, L., & Rogaeva, E. (2020). DNA methylation age acceleration is associated with ALS age of onset and survival. <em>Acta Neuropathologica</em>. https://doi.org/10.1007/s00401-020-02131-z

Vancouver

Zhang M, McKeever PM, Xi Z, Moreno D, Sato C, Bergsma T, et al. DNA methylation age acceleration is associated with ALS age of onset and survival. Acta Neuropathologica. 2020. doi:10.1007/s00401-020-02131-z.

BibTeX

@article{ming2020DNAmet, title = {DNA methylation age acceleration is associated with ALS age of onset and survival}, author = {Ming Zhang and Paul M. McKeever and Zhengrui Xi and Danielle Moreno and Christine Sato and Tessa Bergsma and Philip McGoldrick and Julia Keith and Janice Robertson and Lorne Zinman and Ekaterina Rogaeva}, journal = {Acta Neuropathologica}, year = {2020}, doi = {10.1007/s00401-020-02131-z}, }