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DNA Damage Response

Giuseppina Giglia‐Mari, Angelika Zotter, Wim Vermeulen

Cold Spring Harbor Perspectives in Biology · 2010 · ▲ 479 citations

Genomic instability Epigenetic alterations

Abstract

Structural changes to DNA severely affect its functions, such as replication and transcription, and play a major role in age-related diseases and cancer. A complicated and entangled network of DNA damage response (DDR) mechanisms, including multiple DNA repair pathways, damage tolerance processes, and cell-cycle checkpoints safeguard genomic integrity. Like transcription and replication, DDR is a chromatin-associated process that is generally tightly controlled in time and space. As DNA damage can occur at any time on any genomic location, a specialized spatio-temporal orchestration of this defense apparatus is required.

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Provenance

Source: OpenAlex
DOI: 10.1101/cshperspect.a000745
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Fetched: 2026-06-09 MST

Cite this

APA

Giglia‐Mari, G., Zotter, A., & Vermeulen, W. (2010). DNA Damage Response. <em>Cold Spring Harbor Perspectives in Biology</em>. https://doi.org/10.1101/cshperspect.a000745

Vancouver

Giglia‐Mari G, Zotter A, Vermeulen W. DNA Damage Response. Cold Spring Harbor Perspectives in Biology. 2010. doi:10.1101/cshperspect.a000745.

BibTeX

@article{giuseppina2010DNADam, title = {DNA Damage Response}, author = {Giuseppina Giglia‐Mari and Angelika Zotter and Wim Vermeulen}, journal = {Cold Spring Harbor Perspectives in Biology}, year = {2010}, doi = {10.1101/cshperspect.a000745}, }