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DNA damage and mutation. Types of DNA damage

Stoyan Chakarov, St. Kliment Ohridsky", Rumena Petkova, Scientific Technological Service, George Ch. Russev, Nikolai Zhelev

Biodiscovery · 2014 · ▲ 33 citations

Genomic instability Human Review

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Abstract

This review outlines the basic types of DNA damage caused by exogenous and endogenous factors, analyses the possible consequences of each type of damage and discusses the need for different types of DNA repair. The mechanisms by which a minor damaging event to DNA may eventually result in the introduction of heritable mutation/s are reviewed. The major features of the role of DNA damage in ageing and carcinogenesis are outlined and the role of iatrogenic DNA damage in human health and disease (with curative intent as well as a long-term adverse effect of genotoxic therapies) are discussed in detail.

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Provenance

Source: OpenAlex
DOI: 10.7750/biodiscovery.2014.11.1
Canonical: link ↗
Fetched: 2026-10-26 MST

Cite this

APA

Chakarov, S., Ohridsky", S.K., Petkova, R., Service, S.T., Russev, G.C., & Zhelev, N. (2014). DNA damage and mutation. Types of DNA damage. <em>Biodiscovery</em>. https://doi.org/10.7750/biodiscovery.2014.11.1

Vancouver

Chakarov S, Ohridsky" SK, Petkova R, Service ST, Russev GC, Zhelev N. DNA damage and mutation. Types of DNA damage. Biodiscovery. 2014. doi:10.7750/biodiscovery.2014.11.1.

BibTeX

@article{stoyan2014DNAdam, title = {DNA damage and mutation. Types of DNA damage}, author = {Stoyan Chakarov and St. Kliment Ohridsky" and Rumena Petkova and Scientific Technological Service and George Ch. Russev and Nikolai Zhelev}, journal = {Biodiscovery}, year = {2014}, doi = {10.7750/biodiscovery.2014.11.1}, }