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DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation

Cold Spring Harbor Perspectives in Biology · 2013 · ▲ 873 citations

Genomic instability Mitochondrial dysfunction Human Review

Abstract

Emphasis has been placed in this article dedicated to DNA damage on recent aspects of the formation and measurement of oxidatively generated damage in cellular DNA in order to provide a comprehensive and updated survey. This includes single pyrimidine and purine base lesions, intrastrand cross-links, purine 5',8-cyclonucleosides, DNA-protein adducts and interstrand cross-links formed by the reactions of either the nucleobases or the 2-deoxyribose moiety with the hydroxyl radical, one-electron oxidants, singlet oxygen, and hypochlorous acid. In addition, recent information concerning the mechanisms of formation, individual measurement, and repair-rate assessment of bipyrimidine photoproducts in isolated cells and human skin upon exposure to UVB radiation, UVA photons, or solar simulated light is critically reviewed.

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Provenance

Source: OpenAlex
DOI: 10.1101/cshperspect.a012559
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Fetched: 2026-07-29 MST

Cite this

APA

Cadet, J., & Wagner, J.R. (2013). DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation. <em>Cold Spring Harbor Perspectives in Biology</em>. https://doi.org/10.1101/cshperspect.a012559

Vancouver

Cadet J, Wagner JR. DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation. Cold Spring Harbor Perspectives in Biology. 2013. doi:10.1101/cshperspect.a012559.

BibTeX

@unpublished{jean2013DNABas, title = {DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation}, author = {Jean Cadet and J. Richard Wagner}, journal = {Cold Spring Harbor Perspectives in Biology}, year = {2013}, doi = {10.1101/cshperspect.a012559}, }