Open access · CC-BY via OpenAlex

Current understanding of eryptosis: mechanisms, physiological functions, role in disease, pharmacological applications, and nomenclature recommendations

Anton Tkachenko, Mohammad A. Alfhili, Jawaher Alsughayyir, Alessandro Attanzio, Abdulla Al Mamun Bhuyan, Bożena Bukowska, Antonio Cilla, Martha Angélica Quintanar Escorza, Michael Föller, Ondřej Havránek, Kashif Jilani, Anatolii Onishchenko, Etheresia Pretorius, Volodymyr Prokopіuk, Ignazio Restivo

Cell Death and Disease · 2025 · ▲ 28 citations

Mitochondrial dysfunction Review

＋ Sign in to save

Abstract

ionophores. This cell death is associated with apoptosis-like morphological signs, including cell shrinkage, membrane blebbing, and phosphatidylserine externalization. To emphasize that mature erythrocytes don't have the apoptotic mitochondrial machinery and distinguish this unique cell death modality from apoptosis, it was named "eryptosis". Over recent decades, our knowledge of eryptosis has been significantly expanded, providing more insights into the uniqueness of cell death pathways in erythrocytes. In this review, we aim to summarize our current understanding of eryptosis, formulate the nomenclature and guidelines to interpret results of eryptosis studies, provide a synopsis of morphological and biochemical features of eryptosis, and highlight the role of eryptosis in health and disease, including its druggability.

◌ CITATION ONLY
Full text is not openly licensed for redistribution here. Read it at the source:

Read at source →

Provenance

Source: OpenAlex
DOI: 10.1038/s41419-025-07784-w
Canonical: link ↗
Fetched: 2026-06-05 MST

Cite this

APA

Tkachenko, A., Alfhili, M.A., Alsughayyir, J., Attanzio, A., Bhuyan, A.A.M., Bukowska, B., Cilla, A., Escorza, M.A.Q., Föller, M., Havránek, O., Jilani, K., Onishchenko, A., Pretorius, E., Prokopіuk, V., Restivo, I., Tesoriere, L., Virzì, G.M., & Wieder, T. (2025). Current understanding of eryptosis: mechanisms, physiological functions, role in disease, pharmacological applications, and nomenclature recommendations. <em>Cell Death and Disease</em>. https://doi.org/10.1038/s41419-025-07784-w

Vancouver

Tkachenko A, Alfhili MA, Alsughayyir J, Attanzio A, Bhuyan AAM, Bukowska B, et al. Current understanding of eryptosis: mechanisms, physiological functions, role in disease, pharmacological applications, and nomenclature recommendations. Cell Death and Disease. 2025. doi:10.1038/s41419-025-07784-w.

BibTeX

@article{anton2025Curren, title = {Current understanding of eryptosis: mechanisms, physiological functions, role in disease, pharmacological applications, and nomenclature recommendations}, author = {Anton Tkachenko and Mohammad A. Alfhili and Jawaher Alsughayyir and Alessandro Attanzio and Abdulla Al Mamun Bhuyan and Bożena Bukowska and Antonio Cilla and Martha Angélica Quintanar Escorza and Michael Föller and Ondřej Havránek and Kashif Jilani and Anatolii Onishchenko and Etheresia Pretorius and Volodymyr Prokopіuk and Ignazio Restivo and Luisa Tesoriere and Grazia Maria Virzì and Thomas Wieder}, journal = {Cell Death and Disease}, year = {2025}, doi = {10.1038/s41419-025-07784-w}, }