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Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk

Wei Guo, Bin Zhang, Kun Mu, Shiqing Feng, Zhan‐Yin Dong, Guangzhi Ning, Haoran Li, Shen Liu, Ling Zhao, Yan Li, Bingbing Yu, Huiquan Duan, Chao Sun, Yongjin Li

Cell Death and Disease · 2018 · ▲ 70 citations

Altered intercellular communication

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Abstract

Intervertebral disc degeneration (IDD) is an important factor leading to low back pain, but the underlying mechanisms remain poorly understood. Compared with normal nucleus pulposus (NP) tissues, the expression of circ-GRB10 was downregulated in IDD. Furthermore, overexpression of circ-GRB10 inhibited NP cell apoptosis. circ-GRB10 could sequester miR-328-5p, which could potentially lead to the upregulation of target genes related to cell proliferation via the ErbB pathway. In conclusion, the present study revealed that circ-GRB10/miR-328-5p/ERBB2 signaling pathway is involved in IDD development, suggesting that circ-GRB10 might be a novel therapeutic target for IDD.

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Provenance

Source: OpenAlex
DOI: 10.1038/s41419-017-0232-z
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Fetched: 2026-06-23 MST

Cite this

APA

Guo, W., Zhang, B., Mu, K., Feng, S., Dong, Z., Ning, G., Li, H., Liu, S., Zhao, L., Li, Y., Yu, B., Duan, H., Sun, C., & Li, Y. (2018). Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk. <em>Cell Death and Disease</em>. https://doi.org/10.1038/s41419-017-0232-z

Vancouver

Guo W, Zhang B, Mu K, Feng S, Dong Z, Ning G, et al. Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk. Cell Death and Disease. 2018. doi:10.1038/s41419-017-0232-z.

BibTeX

@article{wei2018Circul, title = {Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk}, author = {Wei Guo and Bin Zhang and Kun Mu and Shiqing Feng and Zhan‐Yin Dong and Guangzhi Ning and Haoran Li and Shen Liu and Ling Zhao and Yan Li and Bingbing Yu and Huiquan Duan and Chao Sun and Yongjin Li}, journal = {Cell Death and Disease}, year = {2018}, doi = {10.1038/s41419-017-0232-z}, }