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ChAMP: updated methylation analysis pipeline for Illumina BeadChips

Yuan Tian, Tiffany Morris, Amy P. Webster, Zhen Yang, Stephan Beck, Andrew Feber, Andrew E. Teschendorff

Bioinformatics · 2017 · ▲ 1,232 citations

Epigenetic alterations Human

Abstract

SUMMARY: The Illumina Infinium HumanMethylationEPIC BeadChip is the new platform for high-throughput DNA methylation analysis, effectively doubling the coverage compared to the older 450 K array. Here we present a significantly updated and improved version of the Bioconductor package ChAMP, which can be used to analyze EPIC and 450k data. Many enhanced functionalities have been added, including correction for cell-type heterogeneity, network analysis and a series of interactive graphical user interfaces. AVAILABILITY AND IMPLEMENTATION: ChAMP is a BioC package available from https://bioconductor.org/packages/release/bioc/html/ChAMP.html. CONTACT: [email protected] or [email protected] or [email protected]. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

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Provenance

Source: OpenAlex
DOI: 10.1093/bioinformatics/btx513
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Fetched: 2026-08-22 MST

Cite this

APA

Tian, Y., Morris, T., Webster, A.P., Yang, Z., Beck, S., Feber, A., & Teschendorff, A.E. (2017). ChAMP: updated methylation analysis pipeline for Illumina BeadChips. <em>Bioinformatics</em>. https://doi.org/10.1093/bioinformatics/btx513

Vancouver

Tian Y, Morris T, Webster AP, Yang Z, Beck S, Feber A, et al. ChAMP: updated methylation analysis pipeline for Illumina BeadChips. Bioinformatics. 2017. doi:10.1093/bioinformatics/btx513.

BibTeX

@article{yuan2017ChAMPu, title = {ChAMP: updated methylation analysis pipeline for Illumina BeadChips}, author = {Yuan Tian and Tiffany Morris and Amy P. Webster and Zhen Yang and Stephan Beck and Andrew Feber and Andrew E. Teschendorff}, journal = {Bioinformatics}, year = {2017}, doi = {10.1093/bioinformatics/btx513}, }