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Associations Between Grimage Acceleration and Pulmonary Function in the Coronary Artery Risk Development in Young Adults (CARDIA) Study

Brian Thomas Joyce, Xuefen Chen, Tao Gao, Yinan Zheng, Drew Robert Nannini, Lei Liu, Benjamin E. Henkle, Ravi Kalhan, George R. Washko, Ken M. Kunisaki, Bharat Thyagarajan, Douglas E. Vaughan, Myron D. Gross, David R. Jacobs, Donald M. Lloyd‐Jones

Epigenomics · 2023 · ▲ 2 citations

Epigenetic alterations Human

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Abstract

Background: The objective of this research was to determine whether pulmonary function is associated with epigenetic aging (GrimAge) and whether GrimAge predicts emphysema. Methods: This prospective study examined 1042 participants enrolled as part of a community-based longitudinal cohort. The cross-sectional associations between pulmonary function and GrimAge, measured at study year (Y) 20 (participant ages 40–45 years), and prospective associations with emphysema at Y25 were examined. Results: At Y20, forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) were negatively associated with GrimAge; for Y0–Y10 cumulative measures, only the FEV1/FVC ratio was associated with GrimAge at Y15 and Y20. Emphysema at Y25 was associated with GrimAge at Y15 and Y20. Conclusion: Pulmonary function was associated with GrimAge during early and mid-life; GrimAge partially mediated the association between pulmonary function and emphysema.

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Provenance

Source: OpenAlex
DOI: 10.2217/epi-2023-0164
Canonical: link ↗
Fetched: 2026-10-16 MST

Cite this

APA

Joyce, B.T., Chen, X., Gao, T., Zheng, Y., Nannini, D.R., Liu, L., Henkle, B.E., Kalhan, R., Washko, G.R., Kunisaki, K.M., Thyagarajan, B., Vaughan, D.E., Gross, M.D., Jacobs, D.R., Lloyd‐Jones, D.M., & Hou, L. (2023). Associations Between Grimage Acceleration and Pulmonary Function in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. <em>Epigenomics</em>. https://doi.org/10.2217/epi-2023-0164

Vancouver

Joyce BT, Chen X, Gao T, Zheng Y, Nannini DR, Liu L, et al. Associations Between Grimage Acceleration and Pulmonary Function in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Epigenomics. 2023. doi:10.2217/epi-2023-0164.

BibTeX

@unpublished{brian2023Associ, title = {Associations Between Grimage Acceleration and Pulmonary Function in the Coronary Artery Risk Development in Young Adults (CARDIA) Study}, author = {Brian Thomas Joyce and Xuefen Chen and Tao Gao and Yinan Zheng and Drew Robert Nannini and Lei Liu and Benjamin E. Henkle and Ravi Kalhan and George R. Washko and Ken M. Kunisaki and Bharat Thyagarajan and Douglas E. Vaughan and Myron D. Gross and David R. Jacobs and Donald M. Lloyd‐Jones and Lifang Hou}, journal = {Epigenomics}, year = {2023}, doi = {10.2217/epi-2023-0164}, }