Preprint · OA via OpenAlex

Association of 4 epigenetic clocks with measures of functional health, cognition, and all-cause mortality in The Irish Longitudinal Study on Ageing (TILDA)

Cathal McCrory, Giovanni Fiorito, Belinda Hernández, Silvia Polidoro, Aisling M O’Halloran, Ann M. Hever, Clíona Ní Cheallaigh, Ake Tzu-Hui Lu, Steve Horvath, Paolo Vineis, Rose Anne Kenny

bioRxiv (Cold Spring Harbor Laboratory) · 2020 · ▲ 10 citations

Epigenetic alterations Human

＋ Sign in to save

Abstract

ABSTRACT The aging process is characterized by the presence of high interindividual variation between individuals of the same chronical age prompting a search for biomarkers that capture this heterogeneity. The present study examines the associations of four epigenetic clocks - Horvath, Hannum, PhenoAge, GrimAge - with a wide range of clinical phenotypes, and with all-cause mortality at up to 10-year follow-up in a sample of 490 participants in the Irish Longitudinal Study on Ageing. Results indicate that the GrimAge clock represents a step-improvement in the predictive utility of the epigenetic clocks for identifying age-related decline in an array of clinical phenotypes.

◌ CITATION ONLY
Full text is not openly licensed for redistribution here. Read it at the source:

Read at source →

Provenance

Source: OpenAlex
DOI: 10.1101/2020.04.27.063164
Canonical: link ↗
Fetched: 2026-10-16 MST

Cite this

APA

McCrory, C., Fiorito, G., Hernández, B., Polidoro, S., O’Halloran, A.M., Hever, A.M., Cheallaigh, C.N., Lu, A.T., Horvath, S., Vineis, P., & Kenny, R.A. (2020). Association of 4 epigenetic clocks with measures of functional health, cognition, and all-cause mortality in The Irish Longitudinal Study on Ageing (TILDA). <em>bioRxiv (Cold Spring Harbor Laboratory)</em>. https://doi.org/10.1101/2020.04.27.063164

Vancouver

McCrory C, Fiorito G, Hernández B, Polidoro S, O’Halloran AM, Hever AM, et al. Association of 4 epigenetic clocks with measures of functional health, cognition, and all-cause mortality in The Irish Longitudinal Study on Ageing (TILDA). bioRxiv (Cold Spring Harbor Laboratory). 2020. doi:10.1101/2020.04.27.063164.

BibTeX

@unpublished{cathal2020Associ, title = {Association of 4 epigenetic clocks with measures of functional health, cognition, and all-cause mortality in The Irish Longitudinal Study on Ageing (TILDA)}, author = {Cathal McCrory and Giovanni Fiorito and Belinda Hernández and Silvia Polidoro and Aisling M O’Halloran and Ann M. Hever and Clíona Ní Cheallaigh and Ake Tzu-Hui Lu and Steve Horvath and Paolo Vineis and Rose Anne Kenny}, journal = {bioRxiv (Cold Spring Harbor Laboratory)}, year = {2020}, doi = {10.1101/2020.04.27.063164}, }