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Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease: The Emerging Role of VDAC

Pierpaolo Risiglione, Federica Zinghirino, Maria Carmela Di Rosa, Andrea Magrì, Angela Anna Messina

Biomolecules · 2021 · ▲ 80 citations

Mitochondrial dysfunction Review

Abstract

Alpha-Synuclein (αSyn) is a protein whose function is still debated, as well as its role in modulation of mitochondrial function in both physiological and pathological conditions. Mitochondrial porins or Voltage-Dependent Anion Channel (VDAC) proteins are the main gates for ADP/ATP and various substrates towards the organelle. Furthermore, they act as a mitochondrial hub for many cytosolic proteins, including αSyn. This review analyzes the main aspects of αSyn-mitochondria interaction, focusing on the role of VDAC and its emerging involvement in the pathological processes.

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Provenance

Source: OpenAlex
DOI: 10.3390/biom11050718
Canonical: link ↗
Fetched: 2026-10-27 MST

Cite this

APA

Risiglione, P., Zinghirino, F., Rosa, M.C.D., Magrì, A., & Messina, A.A. (2021). Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease: The Emerging Role of VDAC. <em>Biomolecules</em>. https://doi.org/10.3390/biom11050718

Vancouver

Risiglione P, Zinghirino F, Rosa MCD, Magrì A, Messina AA. Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease: The Emerging Role of VDAC. Biomolecules. 2021. doi:10.3390/biom11050718.

BibTeX

@article{pierpaolo2021AlphaS, title = {Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease: The Emerging Role of VDAC}, author = {Pierpaolo Risiglione and Federica Zinghirino and Maria Carmela Di Rosa and Andrea Magrì and Angela Anna Messina}, journal = {Biomolecules}, year = {2021}, doi = {10.3390/biom11050718}, }