A Monocenter, Double-blind, Comparative, Controlled, Randomized Study to Evaluate the Effect of Active R0090948A at 1%, Compared to Vehicle, on Mitochondria With or Without UV Stress in Healthy Participants.

The study intends to evaluate the skin longevity through mitochondria protection efficacy of cosmetic products after 3 months of product application, under UV exposures or not, followed by skin biopsies. Primary objective: \- To assess the efficacy of the investigational active in skin mitochondria protection, after twelve weeks of product application with or without UV stress, by morphological and texture parameters measurements Secondary objectives: * To assess efficacy on other biomarkers of skin mitochondria with biopsies histological analyses * To assess efficacy by skin colorimetric measurements * To assess efficacy by visual scoring of skin pigmentation and erythema * To assess efficacy by skin untargeted full proteomic analysis * To assess efficacy by skin metabolomic analysis Safety: to follow the Adverse Events all along the study