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Evidence brief · intervention

Senolytics

Synthesized from 10 indexed sources · 2026-06-03 MST · preview (no AI key)
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Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].

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Sources

  1. [1] The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
  2. [2] Senolytics improve physical function and increase lifespan in old age
  3. [3] Cellular senescence mediates fibrotic pulmonary disease
  4. [4] Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
  5. [5] Senescence and the SASP: many therapeutic avenues
  6. [6] Senolytic CAR T cells reverse senescence-associated pathologies
  7. [7] Cellular senescence drives age-dependent hepatic steatosis
  8. [8] Cellular senescence and senolytics: the path to the clinic
  9. [9] Aging of the Hematopoietic System: Mechanisms, Consequences, and Systemic Interactions.
  10. [10] Cellular Senescence in Skeletal Muscle Aging.
All Senolytics works → Intervention dossier →