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Evidence brief · hallmark

Mitochondrial dysfunction

Synthesized from 10 indexed sources · 2026-06-04 MST · preview (no AI key)
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Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].

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Sources

  1. [1] Oxidants, antioxidants, and the degenerative diseases of aging.
  2. [2] Reactive Oxygen Species, Oxidative Damage, and Antioxidative Defense Mechanism in Plants under Stressful Conditions
  3. [3] Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy
  4. [4] Oxidative Stress and Antioxidant Defense
  5. [5] Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease
  6. [6] Mitochondria, Oxidants, and Aging
  7. [7] Oxidative stress, aging, and diseases
  8. [8] The Free Radical Theory of Aging Matures
  9. [9] Telomerase and chronic inflammation as central molecular links in aging
  10. [10] SIRT1 in Atherosclerosis: Integrative Control of Vascular Metabolism, Inflammation and Aging.
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