Evidence brief · intervention
Microbiome / FMT
Synthesized from 10 indexed sources ·
2026-06-03 MST
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Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].
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Sources
- [1] The “Golden Age” of Probiotics: A Systematic Review and Meta-Analysis of Randomized and Observational Studies in Preterm Infants
- [2] Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
- [3] Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice
- [4] The connection between aging, cellular senescence and gut microbiome alterations: A comprehensive review
- [5] Gerobiotics: probiotics targeting fundamental aging processes
- [6] Probiotics-induced increase of large intestinal luminal polyamine concentration may promote longevity
- [7] Probiotics, prebiotics, synbiotics and other microbiome-based innovative therapeutics to mitigate obesity and enhance longevity via the gut-brain axis
- [8] Heat-killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide promote longevity by modulating aging hallmarks and enhancing immune responses in Caenorhabditis elegans
- [9] Multi-Model Longevity Assays Reveal Lifespan- and Healthspan-Promoting Effects of <i>Bacillus subtilis</i> WTC019.
- [10] Polyamine metabolism as a regulator of cellular and organismal aging.