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Evidence brief · hallmark

Genomic instability

Synthesized from 10 indexed sources · 2026-07-27 MST · preview (no AI key)
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Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].

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Sources

  1. [1] Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies
  2. [2] Signatures of mutational processes in human cancer
  3. [3] An Analysis of Coping in a Middle-Aged Community Sample
  4. [4] Maftools: efficient and comprehensive analysis of somatic variants in cancer
  5. [5] Impotence and Its Medical and Psychosocial Correlates: Results of the Massachusetts Male Aging Study
  6. [6] Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
  7. [7] Mutational landscape and significance across 12 major cancer types
  8. [8] Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
  9. [9] Digging deeper into cancer resistance in the extraordinarily long-lived naked mole-rat
  10. [10] Muscle-Specific Upregulation of Timeless Mediates Exercise-Induced Amelioration of Age-Related Circadian Rhythm Disruption and Cardiac Dysfunction in Drosophila
All Genomic instability works →