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Evidence brief · hallmark

Genomic instability

Synthesized from 10 indexed sources · 2026-06-03 MST · preview (no AI key)
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Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].

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Sources

  1. [1] Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies
  2. [2] An Analysis of Coping in a Middle-Aged Community Sample
  3. [3] Maftools: efficient and comprehensive analysis of somatic variants in cancer
  4. [4] Impotence and Its Medical and Psychosocial Correlates: Results of the Massachusetts Male Aging Study
  5. [5] Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
  6. [6] Mutational landscape and significance across 12 major cancer types
  7. [7] Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
  8. [8] An epigenetic biomarker of aging for lifespan and healthspan
  9. [9] Neuroendocrine-associated epigenetic factors in cellular senescence: mechanisms and therapeutic implications.
  10. [10] Cardiovascular ageing: hallmarks, signaling pathways, diseases and therapeutic targets.
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