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Evidence brief · hallmark

Epigenetic alterations

Synthesized from 10 indexed sources · 2026-07-26 MST · preview (no AI key)
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Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].

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Sources

  1. [1] Modernity and Self-Identity: Self and Society in the Late Modern Age
  2. [2] Integrated genomic analyses of ovarian carcinoma
  3. [3] Guidelines for the Early Management of Patients With Acute Ischemic Stroke
  4. [4] Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013
  5. [5] DNA methylation age of human tissues and cell types
  6. [6] Integrative analysis of 111 reference human epigenomes
  7. [7] DNA methylation patterns and epigenetic memory
  8. [8] Comprehensive molecular characterization of gastric adenocarcinoma
  9. [9] Mapping bioenergetic mechanisms across aging hallmarks: a systematic evidence map and secondary conceptual synthesis
  10. [10] Longitudinal dynamics of organ-specific proteomic aging clocks over a decade of midlife
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