Willard M. Freeman

Pharmacology & Therapeutics · 2018

⊕ Open access · CC-BY

The role of DNA methylation in epigenetics of aging

▲ 402

Nature Aging · 2024

⊕ Open access · CC-BY

A single-cell atlas of the aging mouse ovary

▲ 192

Molecular Metabolism · 2018

⊕ Open access · CC-BY

Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes

▲ 154

Journal of Neuroinflammation · 2011

⊕ Open access · CC-BY

Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment

▲ 138

Frontiers in Aging Neuroscience · 2013

⊕ Open access · CC-BY

Insulin-like growth factor-1 in CNS and cerebrovascular aging

▲ 137

Neurobiology of Aging · 2018

◌ Citation only

Caloric restriction mitigates age-associated hippocampal differential CG and non-CG methylation

▲ 66

Aging Cell · 2021

⊕ Open access · CC-BY

Many chronological aging clocks can be found throughout the epigenome: Implications for quantifying biological aging

▲ 64

Aging Cell · 2017

⊕ Open access · CC-BY

17α‐estradiol acts through hypothalamic pro‐opiomelanocortin expressing neurons to reduce feeding behavior

▲ 49

The Journals of Gerontology Series A · 2015

⊕ Open access · OA

Recent Developments in Understanding Brain Aging: Implications for Alzheimer’s Disease and Vascular Cognitive Impairment

▲ 44

Epigenetics & Chromatin · 2019

⊕ Open access · CC-BY

Early-life DNA methylation profiles are indicative of age-related transcriptome changes

▲ 29

GeroScience · 2023

⊕ Preprint · OA

Assessing tolerability and physiological responses to 17α-estradiol administration in male rhesus macaques

▲ 10

bioRxiv (Cold Spring Harbor Laboratory) · 2017

⊕ Preprint · CC-BY

Caloric restriction mitigates age-associated hippocampal differential CG and non-CG methylation

▲ 5

bioRxiv (Cold Spring Harbor Laboratory) · 2020

⊕ Preprint · CC-BY

Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α

▲ 2

bioRxiv (Cold Spring Harbor Laboratory) · 2022

⊕ Preprint · CC-BY

17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice

▲ 1