Stephan J. Sigrist

Nature Neuroscience · 2013

⊕ Preprint · OA

Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner

▲ 380

Journal of Neuroinflammation · 2022

⊕ Open access · CC-BY

Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model

▲ 116

PLoS Biology · 2016

⊕ Open access · CC-BY

Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release

▲ 114

Cell Death and Disease · 2012

⊕ Open access · CC-BY

Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways

▲ 108

JAMA Network Open · 2022

⊕ Open access · CC-BY

Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline

▲ 102

Alzheimer s Research & Therapy · 2019

⊕ Open access · CC-BY

Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)—study protocol for a randomized controlled trial

▲ 101

Autophagy · 2021

⊕ Open access · CC-BY

Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging

▲ 89

Autophagy · 2013

⊕ Open access · OA

Spermidine-triggered autophagy ameliorates memory during aging

▲ 80

Autophagy · 2016

⊕ Open access · OA

Spermidine boosts autophagy to protect from synapse aging

▲ 67

Scientific Reports · 2019

⊕ Open access · CC-BY

Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses

▲ 56

Neuron · 2025

⊕ Open access · CC-BY

Neuronal autophagy in the control of synapse function

▲ 40

GeroScience · 2021

⊕ Open access · CC-BY

Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length

▲ 40

bioRxiv (Cold Spring Harbor Laboratory) · 2020

⊕ Preprint · CC-BY

The autophagy activator Spermidine ameliorates Alzheimer’s disease pathology and neuroinflammation in mice

▲ 4

bioRxiv (Cold Spring Harbor Laboratory) · 2021

⊕ Preprint · OA

The autophagy activator Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model

▲ 2