Joris Deelen

Nature Communications · 2016

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Genetic and environmental influences interact with age and sex in shaping the human methylome

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Nature Communications · 2019

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A meta-analysis of genome-wide association studies identifies multiple longevity genes

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The Journals of Gerontology Series A · 2014

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GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy

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Nature Communications · 2020

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Multivariate genomic scan implicates novel loci and haem metabolism in human ageing

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AGE · 2011

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Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways

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Nature Aging · 2022

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Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging

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Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2017

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Phenome and genome based studies into human ageing and longevity: An overview

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Nature Aging · 2025

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The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan

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Journal of Internal Medicine · 2023

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Genetics of human longevity: From variants to genes to pathways

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Journal of Cellular and Molecular Medicine · 2023

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Challenges in anti‐aging medicine–trends in biomarker discovery and therapeutic interventions for a healthy lifespan

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Molecular Metabolism · 2024

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Intermittent rapamycin feeding recapitulates some effects of continuous treatment while maintaining lifespan extension

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Science Advances · 2023

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Convergent genomics of longevity in rockfishes highlights the genetics of human life span variation

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EBioMedicine · 2024

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NMR metabolomics-guided DNA methylation mortality predictors

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Aging Cell · 2020

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Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional longevity

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Briefings in Functional Genomics · 2021

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From mutation to mechanism: deciphering the molecular function of genetic variants linked to human ageing

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bioRxiv (Cold Spring Harbor Laboratory) · 2022

⊕ Preprint · OA

Sex-specific regulation of metabolic health and vertebrate lifespan by AMP biosynthesis

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GeroScience · 2025

⊕ Open access · OA

German longevity study reveals novel rare pro-longevity alleles clustering in mTOR signaling pathway

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Immunity & Ageing · 2025

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Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport

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Research Square · 2022

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Convergent genomics of longevity in Rockfishes highlights the genetics of human lifespan variation

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GeroScience · 2025

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Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants

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GeroScience · 2026

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Low genetic risk for coronary artery disease underlies multigenerational longevity and healthy aging

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Research Square · 2021

⊕ Preprint · CC-BY

The genomics of exceptional longevity in rockfishes refine genetic foundations of human lifespan variation

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bioRxiv (Cold Spring Harbor Laboratory) · 2023

⊕ Preprint · CC-BY

Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants

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bioRxiv (Cold Spring Harbor Laboratory) · 2026

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Rare genetic variants in the IIS/mTOR signalling pathway identified in exceptionally long-lived individuals show shared in vitro effects associated with lifespan across species

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2026

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eLife Assessment: Effects of knockdown of autophagy pathway genes on C. elegans longevity are highly condition dependent

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2026

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eLife Assessment: Effects of knockdown of autophagy pathway genes on C. elegans longevity are highly condition dependent

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eLife · 2026

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eLife Assessment: Effects of knockdown of autophagy pathway genes on C. elegans longevity are highly condition dependent

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Research Square · 2022

⊕ Preprint · CC-BY

Genomics of exceptional longevity in rockfishes refines genetic foundations of human lifespan variation

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