Author
Dudley W. Lamming
- Indexed works
- 55
- Total citations
- 7,570
- Active years
- 16
Collaborators
Works in the record
Science 2012
Preprint · OA
Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
Nature Reviews Molecular Cell Biology 2021
Preprint · OA
Molecular mechanisms of dietary restriction promoting health and longevity
Cell Metabolism 2012
Open access · OA
TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO
Journal of Clinical Investigation 2013
Preprint · OA
Rapalogs and mTOR inhibitors as anti-aging therapeutics
Nature Aging 2023
Open access · OA
Targeting the biology of aging with mTOR inhibitors
Aging Cell 2016
Open access · CC-BY
Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer
Cell Metabolism 2013
Open access · OA
A Central Role for mTOR in Lipid Homeostasis
PLoS Biology 2007
Open access · CC-BY
MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae
Aging Cell 2013
Open access · OA
Calorie restriction in humans inhibits the PI 3 K / AKT pathway and induces a younger transcription profile
The Journals of Gerontology Series A 2016
Open access · OA
Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island
Molecular Microbiology 2004
Open access · OA
MicroReview: Small molecules that regulate lifespan: evidence for xenohormesis
Cold Spring Harbor Perspectives in Medicine 2016
Preprint · OA
Inhibition of the Mechanistic Target of Rapamycin (mTOR)–Rapamycin and Beyond
Nature Communications 2019
Open access · CC-BY
A novel rapamycin analog is highly selective for mTORC1 in vivo
Aging Cell 2015
Open access · CC-BY
Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system
Aging Cell 2015
Open access · CC-BY
Sex‐ and tissue‐specific changes in mTOR signaling with age in C57 BL /6J mice
Nature Protocols 2020
Preprint · OA
A toolbox for the longitudinal assessment of healthspan in aging mice
Cell Metabolism 2023
Open access · OA
Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice
Aging Cell 2014
Open access · CC-BY
Depletion of Rictor, an essential protein component of m TORC 2, decreases male lifespan
Aging Cell 2014
Open access · CC-BY
Depletion of Rictor, an essential protein component of m TORC 2, decreases male lifespan
Cell Metabolism 2023
Open access · OA
When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging
Cell Reports 2019
Open access · CC-BY
Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension
Frontiers in Genetics 2012
Open access · CC-BY
Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2
Oncotarget 2015
Open access · CC-BY
Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model
SpringerPlus 2014
Open access · CC-BY
Diminished mTOR signaling: a common mode of action for endocrine longevity factors
Diabetes 2016
Preprint · OA
Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity
Aging 2014
Open access · CC-BY
Rapamycin-induced metabolic defects are reversible in both lean and obese mice
Aging 2013
Open access · CC-BY
Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance
The Journals of Gerontology Series A 2019
Open access · OA
Next Generation Strategies for Geroprotection via mTORC1 Inhibition
GeroScience 2023
Preprint · OA
Blazing a trail for the clinical use of rapamycin as a geroprotecTOR
Translational Medicine of Aging 2021
Open access · CC-BY
The regulation of healthspan and lifespan by dietary amino acids
Nature Aging 2024
Preprint · CC-BY
Late-life protein or isoleucine restriction impacts physiological and molecular signatures of aging
eLife 2020
Open access · CC-BY
Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging
Aging 2018
Preprint · OA
Aging and drug discovery
Cell Metabolism 2024
Open access · OA
A nutrigeroscience approach: Dietary macronutrients and cellular senescence
BMC Biology 2023
Open access · CC-BY
Geroprotector drugs and exercise: friends or foes on healthy longevity?
Aging Cell 2022
Open access · CC-BY
SIRT3 deficiency decreases oxidative metabolism capacity but increases lifespan in male mice under caloric restriction
GeroScience 2023
Preprint · OA
Geroprotective interventions in the 3xTg mouse model of Alzheimer’s disease
GeroScience 2024
Preprint · CC-BY
Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer’s disease
GeroScience 2024
Preprint · CC-BY
Quantification of healthspan in aging mice: introducing FAMY and GRAIL
bioRxiv (Cold Spring Harbor Laboratory) 2023
Preprint · CC-BY
Late-life isoleucine restriction promotes physiological and molecular signatures of healthy aging
bioRxiv (Cold Spring Harbor Laboratory) 2022
Preprint · CC-BY
Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice
Aging Cell 2025
Open access · CC-BY
Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction
GeroScience 2024
Open access · CC-BY
The mouse Social Frailty Index (mSFI): a novel behavioral assessment for impaired social functioning in aging mice
Nature Aging 2026
Open access · CC-BY
Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice
Nutrition and Healthy Aging 2018
Open access · CC-BY
Is rapamycin a rapalog?
Cell Press Blue 2026
Open access · CC-BY
The hallmarks of protein and amino acid restriction in aging and longevity
PubMed Central 2026
Preprint · CC-BY
Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice
bioRxiv (Cold Spring Harbor Laboratory) 2023
Preprint · CC-BY
Quantification of healthspan in aging mice: Introducing FAMY and GRAIL
Alzheimer s & Dementia 2023
Open access · OA
Acarbose ameliorates western diet‐induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer’s disease
Innovation in Aging 2018
Open access · OA