Derek M. Huffman

Proceedings of the National Academy of Sciences · 2009

⊕ Open access · OA

Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians

▲ 252

Aging Cell · 2014

⊕ Open access · CC-BY

Low insulin‐like growth factor‐1 level predicts survival in humans with exceptional longevity

▲ 220

Nature Communications · 2018

⊕ Open access · CC-BY

Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice

▲ 167

Frontiers in Genetics · 2018

⊕ Open access · CC-BY

Age- and Tissue-Specific Expression of Senescence Biomarkers in Mice

▲ 128

GeroScience · 2019

⊕ Open access · OA

Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice

▲ 85

GeroScience · 2020

⊕ Open access · OA

Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues

▲ 70

International Journal of Molecular Sciences · 2019

⊕ Open access · CC-BY

Telomeres and Longevity: A Cause or an Effect?

▲ 64

Experimental Gerontology · 2016

⊕ Preprint · OA

Energetic interventions for healthspan and resiliency with aging

▲ 54

The Journals of Gerontology Series A · 2016

⊕ Open access · CC-BY

Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience

▲ 52

GeroScience · 2023

⊕ Preprint · OA

Rejuvenation of cerebromicrovascular function in aged mice through heterochronic parabiosis: insights into neurovascular coupling and the impact of young blood factors

▲ 50

GeroScience · 2022

⊕ Preprint · OA

Old blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling

▲ 47

Aging Cell · 2015

⊕ Open access · CC-BY

Central insulin‐like growth factor‐1 ( IGF ‐1) restores whole‐body insulin action in a model of age‐related insulin resistance and IGF ‐1 decline

▲ 45

Aging · 2022

⊕ Open access · CC-BY

Heterochronic parabiosis: a valuable tool to investigate cellular senescence and other hallmarks of aging

▲ 13

GeroScience · 2021

⊕ Preprint · OA

Einstein-Nathan Shock Center: translating the hallmarks of aging to extend human health span

▲ 9

Frontiers in Aging · 2022

⊕ Open access · CC-BY

An optimized mouse parabiosis protocol for investigation of aging and rejuvenative mechanisms

▲ 7

GeroScience · 2026

⊕ Open access · CC-BY

Plasma-based strategies for systemic rejuvenation: critical perspectives on clinical translation

▲ 2

bioRxiv (Cold Spring Harbor Laboratory) · 2020

⊕ Preprint · CC-BY

Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α

▲ 2

Scientific Reports · 2025

⊕ Open access · CC-BY

Reduced IGF-1 signaling fails to limit Alzheimer’s disease progression in a novel rat model of IGF-1R haploinsufficiency

▲ 1