Author
David Sinclair
- Indexed works
- 40
- Total citations
- 15,655
- Active years
- 17
Collaborators
Works in the record
Nature 2004
Citation only
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Circulation Research 2012
Open access · OA
The Intersection Between Aging and Cardiovascular Disease
Nature Communications 2013
Open access · OA
Metformin improves healthspan and lifespan in mice
Aging 2020
Open access · CC-BY
Why does COVID-19 disproportionately affect older people?
The EMBO Journal 2007
Open access · OA
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
Cell Metabolism 2014
Open access · OA
The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice
The Journals of Gerontology Series A 2010
Open access · OA
Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice
Nature Reviews Molecular Cell Biology 2016
Preprint · OA
Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
Cell 2008
Open access · OA
SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging
Aging Cell 2015
Open access · CC-BY
Interventions to Slow Aging in Humans: Are We Ready?
Circulation Research 2018
Open access · OA
Sirtuins and NAD + in the Development and Treatment of Metabolic and Cardiovascular Diseases
European Heart Journal 2015
Open access · CC-BY
Protective effects of sirtuins in cardiovascular diseases: from bench to bedside
Cell Metabolism 2018
Open access · OA
Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice
PLoS Biology 2007
Open access · CC-BY
MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae
Nature Reviews Molecular Cell Biology 2007
Citation only
The role of nuclear architecture in genomic instability and ageing
Redox Biology 2019
Open access · CC-BY
Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice
Nature Aging 2021
Open access · CC-BY
The economic value of targeting aging
Molecular Microbiology 2004
Open access · OA
MicroReview: Small molecules that regulate lifespan: evidence for xenohormesis
Aging 2009
Open access · CC-BY
Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy
Proceedings of the National Academy of Sciences 1999
Open access · OA
Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae
Nature Communications 2020
Open access · CC-BY
Age and life expectancy clocks based on machine learning analysis of mouse frailty
Aging 2023
Open access · CC-BY
Chemically induced reprogramming to reverse cellular aging
Aging 2012
Open access · CC-BY
The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction
Frontiers in Pharmacology 2016
Open access · CC-BY
Head to Head Comparison of Short-Term Treatment with the NAD+ Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice
Aging Cell 2014
Open access · CC-BY
Dietary restriction involves NAD +‐dependent mechanisms and a shift toward oxidative metabolism
Mechanisms of Ageing and Development 2016
Preprint · OA
C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins
Scientific Reports 2017
Open access · CC-BY
Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise
Ageing Research Reviews 2009
Preprint · OA
The ageing epigenome: Damaged beyond repair?
Aging 2020
Open access · OA
Biomarkers of biological age as predictors of COVID-19 disease severity
Nature Aging 2023
Preprint · OA
Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming
Molecular Metabolism 2017
Open access · CC-BY
Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance
The Journal of Clinical Endocrinology & Metabolism 2023
Open access · OA
Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study
Aging Cell 2009
Open access · OA
NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast
Reproduction 2019
Open access · CC-BY
Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice
Cells 2020
Open access · CC-BY
Administration of Nicotinamide Mononucleotide (NMN) Reduces Metabolic Impairment in Male Mouse Offspring from Obese Mothers
Cellular Reprogramming 2023
Preprint · OA
Sustained Vision Recovery by OSK Gene Therapy in a Mouse Model of Glaucoma
FEBS Letters 2023
Open access · OA
Host–microbiome interactions in nicotinamide mononucleotide (NMN) deamidation
bioRxiv (Cold Spring Harbor Laboratory) 2019
Preprint · CC-BY
Age and life expectancy clocks based on machine learning analysis of mouse frailty
bioRxiv (Cold Spring Harbor Laboratory) 2020
Preprint · CC-BY
Nicotinamide mononucleotide (NMN) deamidation by host-microbiome interactions
2020
Preprint · CC-BY