David M. Sabatini

Cell · 2012

⊕ Open access · OA

mTOR Signaling in Growth Control and Disease

▲ 8,513

Science · 2012

⊕ Preprint · OA

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

▲ 1,233

Nature · 2010

◌ Citation only

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

▲ 659

Cell Metabolism · 2012

⊕ Open access · OA

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

▲ 640

Journal of Clinical Investigation · 2013

⊕ Preprint · OA

Rapalogs and mTOR inhibitors as anti-aging therapeutics

▲ 547

Cell Metabolism · 2017

⊕ Open access · OA

The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway

▲ 541

Proceedings of the National Academy of Sciences · 2017

⊕ Open access · CC-BY

Twenty-five years of mTOR: Uncovering the link from nutrients to growth

▲ 525

Nature · 2012

⊕ Preprint · CC-BY

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival

▲ 466

Trends in Molecular Medicine · 2012

⊕ Open access · OA

Amino acids and mTORC1: from lysosomes to disease

▲ 445

Science · 2013

⊕ Preprint · OA

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

▲ 420

Aging Cell · 2016

⊕ Open access · CC-BY

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer

▲ 362

Cell Metabolism · 2013

⊕ Open access · OA

A Central Role for mTOR in Lipid Homeostasis

▲ 360

Journal of Cell Science · 2019

⊕ Preprint · OA

Nutrient regulation of mTORC1 at a glance

▲ 345

Aging Cell · 2013

⊕ Open access · OA

Calorie restriction in humans inhibits the PI 3 K / AKT pathway and induces a younger transcription profile

▲ 261

Science Advances · 2020

⊕ Open access · CC-BY

MCART1/SLC25A51 is required for mitochondrial NAD transport

▲ 207

Aging Cell · 2014

⊕ Open access · CC-BY

Depletion of Rictor, an essential protein component of m TORC 2, decreases male lifespan

▲ 119

Aging Cell · 2014

⊕ Open access · CC-BY

Depletion of Rictor, an essential protein component of m TORC 2, decreases male lifespan

▲ 118

Frontiers in Genetics · 2012

⊕ Open access · CC-BY

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2

▲ 79

Aging · 2013

⊕ Open access · CC-BY

Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance

▲ 56

eLife · 2024

⊕ Open access · CC-BY

Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity

▲ 39

PMC · 2012

◌ Citation only

Rag GTPase-mediated regulation of mTORC1 by nutrients is necessary for neonatal autophagy and survival

▲ 1