Alexander Tyshkovskiy

Cell Metabolism · 2023

⊕ Open access · OA

Biological age is increased by stress and restored upon recovery

▲ 239

Cell · 2023

⊕ Open access · OA

Distinct longevity mechanisms across and within species and their association with aging

▲ 162

Nature · 2023

⊕ Preprint · CC-BY

Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice

▲ 154

Nature Aging · 2023

⊕ Open access · OA

Multi-omic rejuvenation and lifespan extension on exposure to youthful circulation

▲ 134

Aging · 2023

⊕ Open access · CC-BY

Chemically induced reprogramming to reverse cellular aging

▲ 134

Nature Aging · 2023

⊕ Open access · CC-BY

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

▲ 74

Aging Cell · 2018

⊕ Open access · CC-BY

Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction

▲ 74

eLife · 2023

⊕ Open access · CC-BY

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

▲ 51

Nature · 2026

⊕ Open access · CC-BY

Universal transcriptomic hallmarks of mammalian ageing and mortality

▲ 39

eLife · 2024

⊕ Open access · CC-BY

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

▲ 33

bioRxiv (Cold Spring Harbor Laboratory) · 2024

⊕ Preprint · CC-BY

Transcriptomic Hallmarks of Mortality Reveal Universal and Specific Mechanisms of Aging, Chronic Disease, and Rejuvenation

▲ 30

Aging Cell · 2023

⊕ Open access · CC-BY

Rilmenidine extends lifespan and healthspan in Caenorhabditis elegans via a nischarin I1 ‐imidazoline receptor

▲ 22

Nature Communications · 2026

⊕ Open access · CC-BY

Integrative epigenetics and transcriptomics identify aging genes in human blood

▲ 17

bioRxiv (Cold Spring Harbor Laboratory) · 2021

⊕ Preprint · OA

Multi-omic rejuvenation and lifespan extension upon exposure to youthful circulation

▲ 15

bioRxiv (Cold Spring Harbor Laboratory) · 2022

⊕ Preprint · CC-BY

Longevity and rejuvenation effects of cell reprogramming are decoupled from loss of somatic identity

▲ 14

bioRxiv (Cold Spring Harbor Laboratory) · 2022

⊕ Preprint · CC-BY

Rapamycin treatment during development extends lifespan and healthspan

▲ 11

bioRxiv (Cold Spring Harbor Laboratory) · 2023

⊕ Preprint · CC-BY

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

▲ 7

Aging Cell · 2026

⊕ Open access · CC-BY

In Vivo Chemical Reprogramming Is Associated With a Toxic Accumulation of Lipid Droplets Hindering Rejuvenation

▲ 4

bioRxiv (Cold Spring Harbor Laboratory) · 2020

⊕ Preprint · CC-BY

The landscape of longevity across phylogeny

▲ 4

bioRxiv (Cold Spring Harbor Laboratory) · 2024

⊕ Preprint · CC-BY

A compact protein panel for organ-specific age and chronic disease prediction

▲ 2

bioRxiv (Cold Spring Harbor Laboratory) · 2025

⊕ Preprint · CC-BY

Molecular signatures of longevity identify compounds that extend mouse lifespan and healthspan

▲ 2

bioRxiv (Cold Spring Harbor Laboratory) · 2023

⊕ Preprint · CC-BY

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

▲ 2

eLife · 2023

⊕ Preprint · CC-BY

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

▲ 2

SSRN Electronic Journal · 2022

⊕ Preprint · OA

Naked Mole-Rat Hyaluronan Synthase 2 Promotes Longevity and Enhances Healthspan in Mice

▲ 2

Research Square · 2023

⊕ Preprint · CC-BY

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

▲ 1

bioRxiv (Cold Spring Harbor Laboratory) · 2025

⊕ Preprint · CC-BY

Multi-tissue spatial transcriptomics reveals biological age hotspots in mouse and human aging

▲ 1

bioRxiv (Cold Spring Harbor Laboratory) · 2023

⊕ Preprint · CC-BY

Increased hyaluronan by naked mole-rat HAS2 extends lifespan in mice

▲ 1

Innovation in Aging · 2021

⊕ Open access · CC-BY

Chronic Exposure to Youthful Circulation Leads to Epigenetic Reprogramming and Lifespan Extension

▲ 1

eLife · 2024

⊕ Open access · CC-BY

Reviewer #1 (Public Review): Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

▲ 0

eLife · 2024

⊕ Open access · CC-BY

Author Response: Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

▲ 0

eLife · 2023

⊕ Open access · CC-BY

Reviewer #1 (Public Review): Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

▲ 0

Research Square · 2026

⊕ Preprint · CC-BY

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner

▲ 0

eLife · 2021

⊕ Open access · CC-BY

Author response: Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast

▲ 0

eLife · 2024

⊕ Open access · CC-BY

Reviewer #2 (Public Review): Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

▲ 0

eLife · 2023

⊕ Open access · CC-BY

Reviewer #2 (Public Review): Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

▲ 0

eLife · 2024

⊕ Preprint · CC-BY

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

▲ 0

bioRxiv (Cold Spring Harbor Laboratory) · 2026

⊕ Preprint · CC-BY

Causally measuring aging and rejuvenation through transcriptomic damage

▲ 0

bioRxiv (Cold Spring Harbor Laboratory) · 2021

⊕ Preprint · CC-BY

Rilmenidine mimics caloric restriction via the nischarin I1-imidazoline receptor to extend lifespan in C. elegans

▲ 0

bioRxiv (Cold Spring Harbor Laboratory) · 2026

⊕ Preprint · OA

A genome-scale ORF screen for resilience factors that protect the RPE and restore vision in aged mice

▲ 0