Alessandro Ori‬‬

Molecular Systems Biology · 2020

⊕ Open access · CC-BY

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

▲ 235

Cell Reports · 2021

⊕ Open access · CC-BY

Extensive remodeling of the extracellular matrix during aging contributes to age-dependent impairments of muscle stem cell functionality

▲ 105

Science Advances · 2022

⊕ Open access · CC-BY

Protein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegeneration

▲ 76

Cell Reports · 2022

⊕ Open access · CC-BY

Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction

▲ 72

Autophagy · 2019

⊕ Open access · CC-BY

The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan

▲ 71

BMC Biology · 2018

⊕ Open access · CC-BY

Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging

▲ 66

Nature Communications · 2023

⊕ Open access · CC-BY

IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration

▲ 51

Nature Communications · 2021

⊕ Open access · CC-BY

Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation

▲ 31

bioRxiv (Cold Spring Harbor Laboratory) · 2019

⊕ Preprint · CC-BY

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

▲ 15

bioRxiv (Cold Spring Harbor Laboratory) · 2023

⊕ Preprint · CC-BY

Impaired biogenesis of basic proteins impacts multiple hallmarks of the aging brain

▲ 14

Current Opinion in Systems Biology · 2022

⊕ Open access · CC-BY

Organelle dysfunction and its contribution to metabolic impairments in aging and age-related diseases

▲ 10

bioRxiv (Cold Spring Harbor Laboratory) · 2019

⊕ Preprint · CC-BY

Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism

▲ 8

Nature Communications · 2025

⊕ Open access · CC-BY

Aging and diet alter the protein ubiquitylation landscape in the mouse brain

▲ 8

Nature Communications · 2026

⊕ Open access · CC-BY

Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains

▲ 3

bioRxiv (Cold Spring Harbor Laboratory) · 2023

⊕ Preprint · CC-BY

Analysis of different strains of the turquoise killifish Nothobranchius furzeri identifies transcriptomic signatures associated with heritable lifespan differences

▲ 2

bioRxiv (Cold Spring Harbor Laboratory) · 2020

⊕ Preprint · CC-BY

Mapping sites of carboxymethyllysine modification on proteins reveals its consequences for proteostasis and cell proliferation

▲ 2

bioRxiv (Cold Spring Harbor Laboratory) · 2023

⊕ Preprint · CC-BY

Remodeling of the protein ubiquitylation landscape in the aging vertebrate brain

▲ 1

bioRxiv (Cold Spring Harbor Laboratory) · 2017

⊕ Preprint · CC-BY

Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging

▲ 1

eLife · 2026

⊕ Preprint · CC-BY

Gene function and expression profiling in yeast spores, killifish diapause embryos, and their post-dormant offspring cells

▲ 0

eLife · 2026

⊕ Preprint · CC-BY

Gene function and expression profiling in yeast spores, killifish diapause embryos, and their post-dormant offspring cells

▲ 0